Tuesday, 6th October 9th General Meeting of the International Proteolysis Society 2015

• Residues involved in rate enhancement during intramembrane proteolysis - M Joanne Lemieux
• Ectodomain shedding of CD99 by the metalloprotease meprin β during inflammation and fibrosis - Johannes Prox
• The Metalloprotease-Disintegrin ADAM8 modulates β1 integrin signalling and MMP activities in cancer cells and is an attractive target in tumor therapy. - Joerg W. Bartsch
• Tumourigenesis in a colorectal cancer model is altered in mice deficient in dipeptidyl peptidase 4 (DPP4) or fibroblast activation protein (FAP). - Catherine Abbott
• Lysosomes and lysosomal proteases shape the microenvironment of metastases - Thomas Reinheckel

• Uncovering a transcriptional regulatory role for caspases during endoplasmic reticulum stress-induced cell death - Jennie R Lill
• Caspase-2, a regulator of metabolic homeostasis and its contribution to ageing - Claire H Wilson
• Lysosomal proteases in cancer progression - Christoph Peters
• Utilizing recycling endocytic receptors and lysosomal proteolysis for targeted drug delivery in vivo - Niels Behrendt
• Dipeptidyl peptidase 9 (DPP9): knockin mouse, novel natural substrates and association with cell adhesion, focal adhesion kinase and paxillin. - Mark D Gorrell
• Functions of intracellular serpins in neutrophil serine protease-mediated death - Charaf Benarafa

• Global landscape of HIV protease/host interactions identifies additional functions for HIV protease - Charles Craik
• Triggering of the HIV maturation by light: induced processing by photodegradation of a protease inhibitor - Jan Konvalinka
• Crystal structure of the soluble domain of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protea - Isaura Simoes
• The crystal structure of a C11 cysteine peptidase gives functional insight into TbPNT1, a protein essential for the survival of Trypanosoma brucei. - Jaspreet Grewal
• Structural basis of proline-proline peptide bond specificity of metalloprotease Zmp1 implicated in motility of Clostridium difficile - Ulrich Baumann
• Structure and function of polyglycine hydrolases - Todd A Naumann
• A redox switch shapes the exit pore of Enterobacteriaceal Lon protease to facultatively regulate proteolysis - Wataru Nishii

• The Dipeptidyl Peptidase 4 enzyme family in Hepatocellular Carcinoma. - James M Henderson
• Proteolytic cleavage and the generation and function of an intracellular fragment of the receptor tyrosine kinase, EphB4, in prostate cancer - Adrian Herington
• Activity detection of aspartic proteases using biotinylated inhibitors - Koushi Hidaka
• Proteolysis influences plasticity and cellular behaviors of murine tumorigenic cells - Larissa E Hillebrand
• Effect of 3-hydroxy-3-methylbutyrate  on protein metabolism in whole body and in selected tissues of laboratory rat - Milan Holecek
• Polyphosphate is a novel cofactor for regulation of the classical pathway of complement by the serpin, C1-inhibitor - Lilian Hor
• Investigations of the gingipain propeptides from Porphyromonas gingivalis - Laila Huq
• First structures of Family S46 peptidase reveal exo-peptidase activity in Clan PA peptidases. - Ippei Iizuka
• Design and synthesis of cell - targeted prodrugs of the glutamine antagonist 6-diazo-5-oxo-L-norleucine - Andrej Jančařík
• Opposing effects of glucose on legumain and cysteine cathepsins - Harald T. Johansen
• Patterning of the fly embryo head and tail by Furins and a Perforin-like protein - Travis K Johnson
• Activation of human kallikreins by gingipains – virulence factors from Porphyromonas gingivalis - Magdalena Kalinska
• Partial loss of CALM function impacts on the γ-secretase-mediated Aβ42 production and amyloid deposition in vivo - Kunihiko Kanatsu
• Proteomic identification of natural substrates for Matriptase-2 - Reinhild Kappelhoff
• Mice double-deficient for KLK5 and KLK7 generated by programmable nucleases show altered epidermal barrier - Petr Kasparek
• Prolyl carboxypeptidase activity, expression and localization in primary murine and human cells  - Kaat Kehoe
• Cell-type specific deletion of cathepsin D in mouse brain and breast cancer. - Stephanie Ketterer
• Modulation of protease expression in prostate cancer cells after androgen deprivation/anti-androgen therapies - Thomas Kryza
• Prekallikrein heavy chain crystal structure - Chan Li
• The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition - Lizelle Lubbe
• Importance of glycosylation for legumain and cystatin E/M functions - Ngoc Nguyen Lunde
• Regulation of cathepsin D through a propeptide-binding exosite  - Michael Mares
• Engineering the Ig-like cysteine protease inhibitor chagasin to block signaling in the Wnt and VEGF pathways - Henry Maun
• A two-pronged attack: dual inhibition of plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors. - Sheena McGowan
• The metallocarboxypeptidase M32 family in trypanosomatids. - Gabriela T Niemirowicz

Dinner at your own leisure.