Thursday, 8th October 9th General Meeting of the International Proteolysis Society 2015

• Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease - Taisuke Tomita
• The kinetic and structural characterisation of amyloid-β metabolism by human angiotensin-1-converting enzyme (ACE) - Edward D Sturrock
• Characterization of a variant form of tripeptidyl-peptidase II as the potential causing agent of a neurological disease - Birgitta Tomkinson
• Characterization of the adipose tissue-specific Klk7 knock-out mouse: novel functions for Klk7 in obesity and insulin resistance - Konstanze Zieger
• Inactivation of KLK5 and KLK7 rescues lethal phenotype of Netherton syndrome mouse model - Radislav Sedlacek

• Pathomimetic avatars for live-cell imaging of tumor proteolysis - Bonnie F. Sloane
• New chemical probe technologies for diagnostic and intra-operative imaging applications - Matthew Bogyo
• Design of hybrid internally quenched substrates library for investigation of endopeptidases - Marcin Drag
• CRISPR-based mutation of inflammatory caspases for selective in vivo imaging of cell death using engineered activity-based probes - Laura E Sanman
• GCPII as an address for cancer imaging and drug delivery - Tomas Knedlik

• Releasing the brakes in coagulation Factor IXa by cooperative maturation of the substrate binding site and communication through the Ile212-Ile213 motif - Line H Kristensen
• Design, synthesis and early SAR exploration of potent and selective Cathepsin V inhibitor - Rich Williams
• Orally bioavailable prodrugs of 2-phosphonomethyl pentanedioic acid (2-PMPA) a potent and specific inhibitor of glutamate carboxy peptidase II (GCPII)  - Pavel Majer
• TIMPless systems reveal new biology - Rama Khokha

Bob Lazarus, IPS President

Introduction to the Honorary Lifetime Member for 2015 Award

• A journey with matrix metalloproteinases  - Hideaki Nagase