Wednesday, 7th October 9th General Meeting of the International Proteolysis Society 2015

• Building an alternate amplification loop: protein engineering of factor x to restore coagulation - Grant E Blouse
• The crystal structure of the zymogen Factor VII:sTF complex: A highly disordered active-site and its implication for the activation of Factor VII - Anders B Sorensen
• Effect of pancreas-specific ATG5-deficiency on zymogen activation and characteristic of chronic pancreatitis in mice - Walter Halangk
• Design of novel, highly selective factor XIa inhibitor from krait venom - Manjunatha Kini

• Drug discovery on challenging targets: inhibiting the alternative complement pathway with small molecules - Holger Sellner
• Polyphosphate is a novel cofactor for regulation of the classical pathway of complement by the serpin, C1-inhibitor - Lakshmi C Wijeyewickrema
• Novel structure of a prostate cancer-specific marker, Prostate Specific Antigen (KLK3), in complex with an avian diagnostic antibody - Paul J Conroy
• Direct and allosteric mechanisms of KLK4 inhibition revealed by structure and dynamics - Ashley Buckle
• Cell-wall proteolysis in signalling in pseudomonas aeruginosa,a nexus for the induction of antibiotic resistance     - Shahriar Mobashery
• The First Look at a Novel Antimalarial Target? Crystal Structure and Substrate Fingerprint of P. falciparum Prolyl Aminopeptidase - Nyssa Drinkwater
• Engineering peptide inhibitors of PCSK9 for LDL cholesterol lowering - Daniel Kirchhofer

• Development of a multiplexed proteomic platform to quantitate deubiquitinase activity across biological samples - Ingrid Wertz
• Multiplexed in vivo screening identifies a serine hydrolase as a critical regulator of metastatic seeding in pancreatic cancer. - Christopher J Schulze
• Intracellular FRET-based assay for redesigning the specificity of secreted proteases - Jennifer L Guerrero
• EnPlex: A high-throughput method for family-wide profiling of enzyme activity - Daniel Bachovchin

• MT4-MMP (MMP17) as a therapeutic target in metastatic solid tumors - Agnes NOEL
• Design, synthesis and activity of novel macrocyclic inhibitors of human cathepsin D - Lenka Pallova
• Omp19 of Brucella abortus is a broad spectrum protease inhibitor from I38 family - Karina A Pasquevich
• New selective internally quenched substrates for the investigation of human matrix metalloproteinases 2 and 9 - Marcin Poreba
• Studies on the Interaction of Plasminogen and Streptokinase - Adam Juinn Quek
• Rational design of cyclic peptide inhibitors of matriptase - Pedro M Quimbar
• Investigation of ACE and POP hydrolysis in the pathophysiology of constrictive tuberculous pericarditis - Vinasha VR Ramasamy
• Interleukin-6 induces secretion of SPINK1 and trypsin in colorectal cancer - Kati Räsänen
• Visualization of kallikreins in thyroid epithelial cells and keratinocytes - Maren Rehders
• New, specific fluorogenic substrates containing unnatural amino acids for 20S proteasome investigation - Wioletta Rut
• Structural and mutational studies of dipeptidyl peptidase 11 from Porphyromonas gingivalis. - Yasumitsu Sakamoto
• Glycolytic disruption in macrophages is a signal for NLRP3 inflammasome formation and pyroptosis - Laura Sanman
• RLR1 and RLR2, two novel Arabidopsis thaliana atypical aspartic proteases involved in primary root development and lateral root formation - Isaura Simoes
• Parasite aspartic peptidases as therapeutic targets - retro sci-fi? - Daniel Sojka
• Novel legumain-specific activity based probes binds and inhibits legumain in living cells - Rigmor Solberg
• Structures of cathepsin D and its inhibitor involved in plant-insect interaction - Jaroslav Srp
• Characterization of the intestinal proline-specific peptidases complex of tenebrio molitor. study of Cry1Ac and Cry3Aa toxins influence on the expression of their genes. - Valeriia Tereshchenkova
• Molecular model of human prothrombinase complex based on the crystal structure of Pseutarin C - Fatma Isık Ustok
• The importance of perivascular adipose tissue in pathogenesis of abdominal aortic aneurysm - Emina Vorkapic
• Down-regulation of legumain activity in melanoma cells by cystatins C and E/M - Hanna Wallin
• Identifying protease targets of the Drosophila serine protease inhibitor Serpin4 - James Whisstock
• The x-ray crystal structure of microplasmin with a small-molecular active site inhibitor PSI-112 - Guojie Wu
• Investigation of ABM1,2,3 domain within gingipain sequences from Porphyromonas gingivalis - Lianyi Zhang

Dinner at your own leisure.