Monday, 5th October 9th General Meeting of the International Proteolysis Society 2015

• Granzyme B in aging, extracellular matrix remodelling and impaired healing - David J Granville
• Dual functionality of tryptase protomers acting as both proteases and cofactors in their tetrameric and engineered dimeric states - Henry Maun
• Acceleration of diabetic wound healing using a novel protease-anti-protease combination therapy - Mayland Chang
• Structural studies on plasminogen activation and plasmin inhibition - Ruby HP Law
• Invadolysin – an odyssey from chromosomes to lipid droplets to serum protease - Margarete Heck

• Evidence that intracellular and extracellular signalling, initiated by cell surface proteolysis, can be important in cancer of the prostate and ovary - John Hooper
• Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion - Shishir Pant
• A selective pro-angiogenic multifunctional protein extracted from Crataeva tapia bark - Maria Luiza V Oliva
• A novel bone degradation pathway in primary bone cancer, mediated by MMP activity and collagen endocytosis - Lars H Engelholm
• Cancer associated proteases: not just the extracellular matrix anymore - James W Janetka
• Role of membrane-anchored serine proteases in breast carcinogenesis - Karin List

• Regulation of the shedding activity of metalloprotease meprin β in Alzheimer’s disease - Christoph Becker-Pauly
• Next-generation degradomics – navigating substrate degradomes with quantitative digital terminome maps - Ulrich auf dem Keller
• Novel intracellular roles of MMP12 in breast cancer that will make you SYK - Antoine Dufour
• Global profiling of kallikrein-related peptidase 4 (KLK4) substrates and downstream regulated genes in prostate cancer - Ruth A Fuhrman-Luck
• Proteolytic processing in the progression of low-grade astrocytomas to glioblastoma multiforme - Oliver Schilling

• A new inhibitor from rice for prolyl tripeptidyl peptidase from porphyromonas gingivalis - Hirona Agata
• Correlation of B-allele cystatin C with disease? - Freddi Andersson
• Structural basis of peptide binding to dipeptidyl peptidases of Porphyromonas sp. - Gustavo Arruda Bezerra
• Identification of a Metacaspase protein substrate conserved among early divergent eukaryotic cells - Leon A Bouvier
• Developing potent uPA/NHE1 inhibitors with high selectivity over related TLSPs from the clinical drug amiloride - Benjamin J Buckley
• Unravelling interconnections of plasmin in the protease web using TAILS - Georgina Butler
• Functional validation of PSA coding variants associated with prostate cancer risk - Judith Clements
• A molecular dynamics study of a widely-conserved, sequence motif from the C-terminal of the gingipains. - Keith J Cross
• Expression and function of the kallikrein–related peptidase 7 in human melanoma - Dalila Darmoul
• The N-terminal domain of caspase-7 contains exosites for multiple substrates - Jean-Bernard Denault
• Caspase-7 and PARP-1 interact via an exosite - Alexandre Desroches
• Determinant role of the zinc-binding group in the potency and selectivity of synthetic Inhibitors of MMPs - Vincent Dive
• Characterization of KLK14 activity and development of specific substrates - Grzegorz Dubin
• Engineering substrate specificity of SplB and SplE serine proteases of Staphylococcus aureus - Grzegorz Dubin
• Establishing legumain activity as a biomarker for inflammatory bowel disease - Laura E Edgington-Mitchell
• New types of conserved C1 family cysteine cathepsins in insects - Elena N Elpidina
• Modulation of the Thimet Oligopeptidase activity by hydrogen peroxide - Juliana C Ferreira
• N-Domain selective angiotensin-I converting enzyme (ACE) inhibitors using computer aided drug design (CADD) Approaches - Stephen Fienberg
• Characterization and prediction in a computational representation of the protease web - Nikolaus Fortelny
• Proteome analysis of interstitial fluid from murine breast cancers with differential cathepsin B expression - Alejandro Gomez Auli
• The dipeptidyl peptidase and endopeptidase fibroblast activation protein (FAP) in liver disease - Mark D Gorrell
• Structural and Functional Characterization of Human Mast Cell Tryptases - Maresa Grundhuber
• Phenyl esters are potent inhibitors of caseinolytic protease P and reveal a stereogenic switch for deoligomerization - Mathias W. Hackl
• Multiple legumains in ticks - David Hartmann

Dinner at your own leisure.

Please see links below for suggestions on what to do:

• https://innercircle.shangri-la.com/inspiration/penang/heart-and-craft.html
• https://www.facebook.com/MYeatplayshop